Folate (categories 2)
Folate range (<40 vs >=40)
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
27.6439848
|
1
|
<0.0001
|
***
|
|
Folate_gp2
|
0.6834872
|
1
|
0.4
|
ns
|
|
Study
|
0.6172392
|
1
|
0.4
|
ns
|
|
GA_samp
|
20.6035106
|
1
|
<0.0001
|
***
|
|
Folate_gp2:Study
|
0.0906157
|
1
|
0.8
|
ns
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
5.1369360
|
1
|
0.02
|
*
|
|
Folate_gp2
|
0.4004384
|
1
|
0.5
|
ns
|
|
Study
|
0.5113037
|
1
|
0.5
|
ns
|
|
GA_samp
|
312.9945968
|
1
|
<0.0001
|
***
|
|
Folate_gp2:Study
|
1.1235867
|
1
|
0.3
|
ns
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
29.6153063
|
1
|
<0.0001
|
***
|
|
Folate_gp2
|
0.2043583
|
1
|
0.7
|
ns
|
|
Study
|
0.0349007
|
1
|
0.9
|
ns
|
|
GA_samp
|
95.2457244
|
1
|
<0.0001
|
***
|
|
Folate_gp2:Study
|
1.0402265
|
1
|
0.3
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp2
|
1
|
Inf
|
2.526
|
2.526
|
0.1
|
ns
|
|
3
|
Study
|
1
|
Inf
|
4.145
|
4.145
|
0.04
|
*
|
|
4
|
GA_samp
|
1
|
Inf
|
0.850
|
0.850
|
0.4
|
ns
|
|
2
|
Folate_gp2:Study
|
1
|
Inf
|
0.158
|
0.158
|
0.7
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp2
|
1
|
Inf
|
2.907
|
2.907
|
0.09
|
ns
|
|
3
|
Study
|
1
|
Inf
|
7.737
|
7.737
|
0.005
|
**
|
|
4
|
GA_samp
|
1
|
Inf
|
0.384
|
0.384
|
0.5
|
ns
|
|
2
|
Folate_gp2:Study
|
1
|
Inf
|
0.184
|
0.184
|
0.7
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp2
|
1
|
Inf
|
0.810
|
0.810
|
0.4
|
ns
|
|
3
|
Study
|
1
|
Inf
|
28.313
|
28.313
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.623
|
0.623
|
0.4
|
ns
|
|
2
|
Folate_gp2:Study
|
1
|
Inf
|
0.099
|
0.099
|
0.8
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
14.15 (5.63, 35.42)
|
<0.0001
|
|
Folate_gp2≥40
|
1.13 (0.95, 1.34)
|
0.19
|
|
StudySTOP
|
1.14 (0.83, 1.57)
|
0.43
|
|
GA_samp
|
1.14 (1.08, 1.20)
|
<0.0001
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.68 (1.00, 2.78)
|
0.04
|
|
Folate_gp2≥40
|
1.04 (0.94, 1.15)
|
0.47
|
|
StudySTOP
|
1.20 (1.00, 1.44)
|
0.05
|
|
GA_samp
|
1.33 (1.29, 1.38)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.17 (0.09, 0.33)
|
<0.0001
|
|
Folate_gp2≥40
|
0.92 (0.81, 1.06)
|
0.25
|
|
StudySTOP
|
0.92 (0.72, 1.18)
|
0.52
|
|
GA_samp
|
1.22 (1.17, 1.27)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
20.52 (5.45, 77.29)
|
<0.0001
|
|
Folate_gp2≥40
|
0.79 (0.62, 1.02)
|
0.08
|
|
StudySTOP
|
0.62 (0.39, 0.99)
|
0.05
|
|
GA_samp
|
1.04 (0.96, 1.13)
|
0.34
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
6.49 (1.56, 26.94)
|
0.01
|
|
Folate_gp2≥40
|
0.76 (0.57, 1.00)
|
0.05
|
|
StudySTOP
|
0.49 (0.30, 0.81)
|
0.005
|
|
GA_samp
|
1.03 (0.94, 1.13)
|
0.51
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
6.85 (5.37, 8.74)
|
<0.0001
|
|
Folate_gp2≥40
|
0.96 (0.88, 1.04)
|
0.30
|
|
StudySTOP
|
0.79 (0.73, 0.86)
|
<0.0001
|
|
GA_samp
|
0.99 (0.97, 1.01)
|
0.53
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
70.73103
|
14.73149
|
52.79746
|
46.57671
|
107.4116
|
|
STOP
|
80.59937
|
13.34623
|
22.89233
|
57.21742
|
113.5364
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
61.21751
|
4.864402
|
119.13250
|
52.30512
|
71.64849
|
|
STOP
|
73.28061
|
3.084380
|
30.03457
|
67.24489
|
79.85809
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
1.900528
|
0.2060202
|
135.66754
|
1.533812
|
2.354921
|
|
STOP
|
1.754287
|
0.0924152
|
39.19691
|
1.577001
|
1.951503
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
29.75754
|
5.993665
|
Inf
|
20.05168
|
44.16144
|
|
STOP
|
18.50744
|
1.470135
|
Inf
|
15.83913
|
21.62526
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
8.117903
|
1.7585737
|
Inf
|
5.309442
|
12.411916
|
|
STOP
|
3.980335
|
0.3401272
|
Inf
|
3.366532
|
4.706048
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
6.143411
|
0.2573602
|
Inf
|
5.659147
|
6.669114
|
|
STOP
|
4.856323
|
0.1075299
|
Inf
|
4.650075
|
5.071717
|
Comparisons (Overall)
|
Hormone
|
Contrast
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
≥40 / <40
|
1.13 (0.94, 1.34)
|
0.2
|
|
hPL (μg/ml)
|
≥40 / <40
|
1.04 (0.94, 1.16)
|
0.5
|
|
GH2 (ng/ml)
|
≥40 / <40
|
0.92 (0.80, 1.06)
|
0.3
|
|
Insulin (uU/ml)
|
≥40 / <40
|
0.79 (0.62, 1.02)
|
0.08
|
|
HOMA-IR
|
≥40 / <40
|
0.76 (0.57, 1.00)
|
0.05
|
|
Glucose (mmol/L)
|
≥40 / <40
|
0.96 (0.88, 1.04)
|
0.3
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)
